The FBXW2 Polyclonal Antibody (CAB15996) is an essential tool for research involving the FBXW2 protein, a key component of the SCF (Skp1-Cullin-F-box) E3 ubiquitin ligase complex. This antibody, derived from rabbit polyclonal sources, is highly specific for human samples and is validated for use in Western blotting applications. By binding to the FBXW2 protein, this antibody enables researchers to detect and analyze FBXW2 expression in a variety of cell types, making it ideal for studies in cell biology and protein degradation pathways.FBXW2 is a critical regulator of protein degradation, playing a key role in the targeted destruction of specific proteins within the cell.
Dysregulation of FBXW2 activity has been linked to various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. By understanding the function and regulation of FBXW2, researchers can uncover new insights into disease mechanisms and potentially identify novel therapeutic targets for intervention.Overall, the FBXW2 Polyclonal Antibody (CAB15996) is a valuable tool for researchers studying protein degradation pathways and investigating the role of FBXW2 in disease processes. Its high specificity and reliability make it a trusted antibody for conducting experiments and furthering our understanding of cellular regulatory mechanisms.
Product Name:
FBXW2 Rabbit Polyclonal Antibody
SKU:
CAB15996
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 102-454 of human FBXW2 (NP_036296.2).
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.
Purification Method:
Affinity purification
Gene ID:
26190
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using FBXW2 Rabbit pAb (CAB15996) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
