The FBXW12 Polyclonal Antibody (PACO36910) is a valuable tool for researchers studying FBXW12, a key component of the ubiquitin-proteasome system involved in protein degradation and cell cycle regulation. This antibody, derived from rabbit immunizations, exhibits high specificity and sensitivity towards human FBXW12 protein, making it an ideal choice for Western blot applications.FBXW12 is a crucial player in maintaining cellular homeostasis by targeting specific proteins for degradation, thereby regulating important cellular processes such as cell division and growth.
Dysregulation of FBXW12 has been linked to various diseases, including cancer and neurodegenerative disorders, highlighting its potential as a therapeutic target. By using the FBXW12 Polyclonal Antibody, researchers can gain valuable insights into the function and expression of FBXW12 in different cell types and disease states, paving the way for the development of targeted treatments and therapies.
Antibody Name:
FBXW12 Antibody (PACO36910)
Antibody SKU:
PACO36910
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human F-box/WD repeat-containing protein 12 protein (1-250AA)
Immunohistochemistry of paraffin-embedded human colon cancer using PACO36910 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human gastric cancer using PACO36910 at dilution of 1:100.
Background:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Synonyms:
F-box/WD repeat-containing protein 12 (F-box and WD-40 domain-containing protein 12) (F-box only protein 35), FBXW12, FBW12 FBXO12 FBXO35
UniProt Protein Function:
FBXW12: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 3p21.31
UniProt Protein Details:
NCBI Summary:
Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
