UniProt Protein Function: | FBXW12: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 3p21.31 |
UniProt Protein Details: | |
NCBI Summary: | Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q6X9E4 |
NCBI GenInfo Identifier: | 133777276 |
NCBI Gene ID: | 285231 |
NCBI Accession: | AAI01307.1 |
UniProt Secondary Accession: | Q6X9E4,Q494Y9, Q494Z0, E9PG36 |
UniProt Related Accession: | Q6X9E4 |
Molecular Weight: | 50,832 Da |
NCBI Full Name: | FBXW12 protein, partial |
NCBI Synonym Full Names: | F-box and WD repeat domain containing 12 |
NCBI Official Symbol: | FBXW12Â Â |
NCBI Official Synonym Symbols: | FBW12; FBXO12; FBXO35Â Â |
NCBI Protein Information: | F-box/WD repeat-containing protein 12 |
UniProt Protein Name: | F-box/WD repeat-containing protein 12 |
UniProt Synonym Protein Names: | F-box and WD-40 domain-containing protein 12; F-box only protein 35 |
Protein Family: | F-box/WD repeat-containing protein |
UniProt Gene Name: | FBXW12Â Â |
UniProt Entry Name: | FBW12_HUMAN |