The FBXW11 Polyclonal Antibody (CAB7784) is a valuable tool for researchers studying FBXW11, a protein involved in the regulation of protein degradation and cell cycle progression. This antibody, produced in rabbits, exhibits high specificity and sensitivity for human samples, making it an ideal choice for Western blot applications.FBXW11, also known as F-box/WD repeat-containing protein 11, is a crucial component of the ubiquitin-proteasome system, a pathway that controls the turnover of proteins involved in cell growth and division. Dysregulation of FBXW11 has been implicated in various diseases, including cancer and neurological disorders, highlighting its importance as a potential therapeutic target.
By using the FBXW11 Polyclonal Antibody, researchers can accurately detect and analyze the expression levels of FBXW11 in different cell types, providing valuable insights into its role in cellular processes. This antibody is a valuable tool for investigations in fields such as cancer biology, cell signaling, and drug development, offering new possibilities for understanding and targeting FBXW11-related pathways in disease.
Product Name:
FBXW11 Rabbit Polyclonal Antibody
SKU:
CAB7784
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 443-542 of human FBXW11 (NP_036432.2).
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons.
Purification Method:
Affinity purification
Gene ID:
23291
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of A-431 cells, using FBXW11 antibody (CAB7784) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
