The FBXW11 Polyclonal Antibody (CAB20010) is a specialized tool for researchers studying the FBXW11 protein, a crucial component in the regulation of protein degradation within the cell. This antibody, produced in rabbits, has been rigorously validated for use in Western blot applications and exhibits high specificity and sensitivity towards human samples.FBXW11, a member of the F-box protein family, is known for its role in the ubiquitin-proteasome pathway, where it targets specific proteins for degradation. Dysregulation of FBXW11 has been linked to various diseases, including cancer, neurodegenerative disorders, and autoimmune conditions.
By using the FBXW11 Polyclonal Antibody, researchers can study the expression and function of FBXW11 in different cellular contexts, providing valuable insights into its role in disease pathogenesis and potential therapeutic interventions.With its high reactivity and specificity, the FBXW11 Polyclonal Antibody is an indispensable tool for investigating the intricate mechanisms of protein degradation and identifying potential therapeutic targets for a wide range of diseases. Add this antibody to your research toolkit today and unlock new possibilities in the field of cellular biology and drug discovery.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons.
Purification Method:
Affinity purification
Gene ID:
23291
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using FBXW11 Rabbit pAb (CAB20010) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
