The FBXW10 Polyclonal Antibody (PAC049206) is a valuable tool for researchers studying the FBXW10 protein, which plays a key role in the regulation of cellular processes. This antibody is produced in rabbits and has been demonstrated to have high reactivity with human samples. It has been validated for use in Western blot applications, allowing for the detection and analysis of the FBXW10 protein in various cell types.FBXW10 is a component of the SCF (Skp1-Cul1-F-box protein) E3 ubiquitin ligase complex, which is involved in targeting proteins for degradation by the proteasome.
The regulation of protein degradation is crucial for maintaining cellular homeostasis, and dysregulation of this process can contribute to the development of diseases such as cancer and neurodegenerative disorders.By studying the function and regulation of FBXW10, researchers can gain insight into the mechanisms that control protein turnover and identify potential therapeutic targets for the treatment of various diseases. The FBXW10 Polyclonal Antibody is a valuable tool for investigating the role of FBXW10 in cellular processes and disease pathology.
Antibody Name:
Fbxw10 Antibody (PACO49206)
Antibody SKU:
PACO49206
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Mouse
Immunogen:
Recombinant Mouse F-box/WD repeat-containing protein 10 protein (701-1030AA)
Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1 (By similarity).
Synonyms:
F-box/WD repeat-containing protein 10 (F-box and WD-40 domain-containing protein 10), Fbxw10
UniProt Protein Function:
FBXW10: Probable substrate-recognition component of a SCF (SKP1- CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1. 4 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 11|11 B2Molecular Function: ubiquitin-protein ligase activity
