The FBXW10 Monoclonal Antibody (PAC036506) is a powerful tool for researchers studying the FBXW10 protein, a key player in the ubiquitin proteasome system. This antibody, produced in mice, is highly specific to human samples and has been validated for use in immunofluorescence and immunohistochemistry applications.FBXW10 is a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which targets specific proteins for degradation. Dysregulation of FBXW10 has been linked to various diseases, including cancer and neurodegenerative disorders.
By targeting FBXW10 with this antibody, researchers can investigate its role in protein degradation pathways and potentially identify novel therapeutic targets for disease treatment.The FBXW10 Monoclonal Antibody is a valuable tool for researchers interested in dissecting the intricate mechanisms of protein degradation and the ubiquitin proteasome system. Its high specificity and sensitivity make it an excellent choice for studies in cancer biology, neurobiology, and other fields where protein turnover plays a crucial role.
Antibody Name:
FBXW10 Antibody (PACO36506)
Antibody SKU:
PACO36506
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human F-box/WD repeat-containing protein 10 protein (701-1000AA)
Immunohistochemistry of paraffin-embedded human colon cancer using PACO36506 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human colon tissue using PACO36506 at dilution of 1:100.
Background:
Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1.
Synonyms:
F-box/WD repeat-containing protein 10 (F-box and WD-40 domain-containing protein 10) (Ubiquitin ligase-specificity factor), FBXW10
UniProt Protein Function:
Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1.
UniProt Protein Details:
NCBI Summary:
Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
