UniProt Protein Function: | Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1. |
UniProt Protein Details: | |
NCBI Summary: | Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q5XX13 |
NCBI GenInfo Identifier: | 34192015 |
NCBI Gene ID: | 10517 |
NCBI Accession: | BC028364 |
UniProt Secondary Accession: | Q5XX13,Q8TC00, Q9H0F0, C9JRY8, C9JZD7 |
UniProt Related Accession: | Q5XX13 |
Molecular Weight: | |
NCBI Full Name: | Homo sapiens F-box and WD repeat domain containing 10, mRNA |
NCBI Synonym Full Names: | F-box and WD repeat domain containing 10 |
NCBI Official Symbol: | FBXW10Â Â |
NCBI Official Synonym Symbols: | HREP; Fbw10; SM25H2; SM2SH2Â Â |
NCBI Protein Information: | F-box/WD repeat-containing protein 10 |
UniProt Protein Name: | F-box/WD repeat-containing protein 10 |
UniProt Synonym Protein Names: | F-box and WD-40 domain-containing protein 10; Ubiquitin ligase-specificity factor |
Protein Family: | F-box/WD repeat-containing protein |
UniProt Gene Name: | FBXW10Â Â |
UniProt Entry Name: | |