The FBXO8 Polyclonal Antibody (CAB17681) is a valuable tool for researchers studying FBXO8, a protein involved in the regulation of cell cycle progression and cell proliferation. This rabbit polyclonal antibody is highly specific to human samples, making it an ideal choice for Western blot applications.FBXO8 is a substrate recognition component of the Skp1-Cul1-F-box protein (SCF) ubiquitin ligase complex, which targets proteins for degradation by the proteasome. The FBXO8 protein plays a crucial role in maintaining cellular homeostasis by regulating the turnover of key signaling molecules involved in cell growth and division.By using the FBXO8 Polyclonal Antibody, researchers can detect and analyze the expression levels of FBXO8 in various cell types, providing valuable insights into its role in cell cycle regulation and proliferation.
This antibody is a valuable tool for studies in cancer research, as dysregulation of FBXO8 has been linked to the development and progression of various types of cancer.Overall, the FBXO8 Polyclonal Antibody (CAB17681) is a reliable reagent for investigating the function of FBXO8 in cell biology, cancer biology, and other related fields of research. Its high specificity and sensitivity make it a valuable asset for researchers seeking to uncover the molecular mechanisms underlying cell cycle control and proliferation.
Product Name:
FBXO8 Rabbit Polyclonal Antibody
SKU:
CAB17681
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 110-250 of human FBXO8 (NP_036312.2).
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity.
Purification Method:
Affinity purification
Gene ID:
26269
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse liver, using FBXO8 Rabbit pAb (CAB17681) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
