The FBXO5 Polyclonal Antibody (CAB18449) is a valuable tool for researchers studying the FBXO5 protein, which plays a key role in cell cycle regulation and protein degradation. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it a reliable tool for Western blot applications. By targeting the FBXO5 protein, researchers can study its role in cell cycle progression, DNA repair, and cancer development.FBXO5, a member of the F-box protein family, is involved in the ubiquitin-proteasome pathway, where it helps target specific proteins for degradation.
Dysregulation of FBXO5 has been linked to various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. Investigating the function of FBXO5 using this antibody can provide valuable insights into the mechanisms underlying these conditions and potentially lead to the development of targeted therapies.
Product Name:
FBXO5 Rabbit Polyclonal Antibody
SKU:
CAB18449
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human FBXO5 (NP_036309.1).
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
26271
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using FBXO5 Rabbit pAb (CAB18449) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
