The FBXO44 Polyclonal Antibody (PAC041074) is specifically designed for research involving FBXO44, a member of the F-box protein family that plays a crucial role in regulating protein degradation and cellular processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By targeting the FBXO44 protein, researchers can effectively detect and analyze its expression in various cell types, making it an ideal tool for investigations in cell biology and cancer research.FBXO44 is known for its involvement in ubiquitin-mediated protein degradation pathways, where it acts as a substrate recognition component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex.
Its function in controlling protein turnover and cellular signaling cascades highlights its significance in maintaining cellular homeostasis and regulating various biological processes. Studying the role of FBXO44 can provide valuable insights into mechanisms underlying disease states, such as cancer, and potentially identify novel therapeutic targets for intervention strategies.
Antibody Name:
FBXO44 Antibody (PACO41074)
Antibody SKU:
PACO41074
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human F-box only protein 44 protein (1-224AA)
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Synonyms:
F-box only protein 44 (F-box protein FBX30) (F-box/G-domain protein 3), FBXO44, FBG3 FBX30 FBX44 FBX6A FBXO6A
UniProt Protein Function:
FBXO44: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 1p36.22Cellular Component: SCF ubiquitin ligase complexMolecular Function: protein binding
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It is also a member of the NFB42 (neural F Box 42 kDa) family, similar to F-box only protein 2 and F-box only protein 6. Several alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Feb 2015]
