The FBXO44 Polyclonal Antibody (PACO09255) is a valuable tool for researchers studying FBXO44, a protein involved in cellular processes such as protein degradation and cell cycle regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By binding to FBXO44, this antibody allows for the detection and analysis of the protein in various cell types, making it an essential component for studies in cell biology and cancer research.
FBXO44 is known for its role in the ubiquitin-proteasome pathway, where it helps target proteins for degradation, thereby regulating key cellular functions. Dysregulation of FBXO44 has been linked to various diseases, including cancer, making it a promising target for therapeutic interventions. By understanding the function of FBXO44, researchers can gain insights into the mechanisms underlying disease progression and potentially develop novel treatment strategies targeting this pathway.
FBXO44: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 1p36.22Cellular Component: SCF ubiquitin ligase complexMolecular Function: protein binding
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It is also a member of the NFB42 (neural F Box 42 kDa) family, similar to F-box only protein 2 and F-box only protein 6. Several alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Feb 2015]
