The FBXO42 Polyclonal Antibody (CAB14899) is a valuable tool for researchers studying FBXO42, a protein involved in the regulation of cellular processes such as protein degradation and cell cycle progression. This antibody, produced in rabbits, exhibits high reactivity with human samples and is specifically validated for use in Western blot applications. By binding to the FBXO42 protein, this antibody allows for the detection and analysis of FBXO42 in a variety of cell types, making it an ideal choice for studies in molecular biology and cancer research.FBXO42 plays a crucial role in regulating the degradation of specific proteins within the cell, impacting key cellular pathways and processes.
Understanding the function of FBXO42 is essential for unraveling its role in disease states such as cancer and neurodegenerative disorders, where dysregulation of protein degradation can lead to pathogenesis. By targeting FBXO42 with this polyclonal antibody, researchers can gain insights into the mechanisms underlying these conditions and explore potential therapeutic interventions aimed at modulating FBXO42 activity.
Product Name:
FBXO42 Rabbit Polyclonal Antibody
SKU:
CAB14899
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 468-717 of human FBXO42 (NP_061867.1).
Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).
Purification Method:
Affinity purification
Gene ID:
54455
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of HeLa cells, using FBXO42 antibody (CAB14899) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
