The FBXO42 Polyclonal Antibody (CAB14898) is a valuable tool for researchers studying FBXO42, a protein involved in the regulation of cellular processes such as protein degradation and cell cycle progression. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blot assays. By binding to the FBXO42 protein, this antibody enables the detection and analysis of FBXO42 expression in a variety of cell types, making it a versatile tool for studies in cell biology and cancer research.
FBXO42 is a member of the F-box protein family, known for their role in substrate recognition for ubiquitin-mediated protein degradation. The function of FBXO42 in cellular processes such as cell cycle control and regulation of protein levels makes it an important target for research into cancer and other diseases. Understanding the role of FBXO42 in these processes is essential for developing targeted therapies that can selectively modulate protein degradation and cell proliferation pathways.
Product Name:
FBXO42 Rabbit Polyclonal Antibody
SKU:
CAB14898
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 468-717 of human FBXO42 (NP_061867.1).
Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).
Purification Method:
Affinity purification
Gene ID:
54455
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of mouse lung, using FBXO42 antibody (CAB14898) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
