The FBXO4 Polyclonal Antibody (CAB9968) is a versatile tool for researchers studying the FBXO4 protein, a crucial component of the ubiquitin-proteasome system involved in protein degradation and cell cycle regulation. This rabbit-raised antibody exhibits high reactivity with human samples and is specifically validated for Western blot applications. By targeting the FBXO4 protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for investigations in molecular biology, cell signaling, and cancer research.FBXO4 is known to play a key role in maintaining cellular homeostasis by targeting specific proteins for degradation, thereby regulating various cellular processes such as cell proliferation, apoptosis, and DNA repair.
Its involvement in protein turnover and cell cycle control highlights its importance in understanding the mechanisms underlying cancer development and progression. By studying the functions of FBXO4, researchers can uncover potential therapeutic targets for cancer treatment and identify novel pathways for intervention in tumorigenesis.
Product Name:
FBXO4 Rabbit Polyclonal Antibody
SKU:
CAB9968
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 138-387 of human FBXO4 (NP_036308.1).
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
26272
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using FBXO4 antibody (CAB9968) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
