The FBXO36 Polyclonal Antibody (PACO64235) is a valuable tool for researchers studying FBXO36, a protein involved in the regulation of cellular processes such as protein degradation and cell cycle control. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for use in Western blotting applications. By binding to the FBXO36 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in molecular biology and cancer research.FBXO36 is known for its role in the ubiquitin-proteasome system, where it acts as a substrate receptor for the SCF (Skp1-Cul1-F-box) E3 ubiquitin ligase complex. Through its involvement in protein degradation, FBXO36 is implicated in the regulation of key cellular processes such as cell division, growth, and differentiation.
Research into the function of FBXO36 is important for understanding its potential role in diseases such as cancer, where dysregulation of protein degradation pathways can contribute to tumor development and progression.By utilizing the FBXO36 Polyclonal Antibody (PACO64235), researchers can gain valuable insights into the function and regulation of FBXO36 in various cellular contexts. This antibody provides a reliable tool for investigating the intricate mechanisms underlying protein degradation and cell cycle control, offering new opportunities for advancing our understanding of molecular pathways relevant to both normal physiology and
Antibody Name:
FBXO36 Antibody (PACO64235)
Antibody SKU:
PACO64235
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
IF:1:100-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human F-box only protein 36 protein (1-188AA)
Immunofluorescence staining of SH-SY5Y cells with PACO64235 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Synonyms:
F-box only protein 36, FBXO36, FBX36
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
Members of the F-box protein family, such as FBXO36, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
