The FBXO30 Polyclonal Antibody (PAC039186) is a valuable tool for researchers studying FBXO30, a protein involved in the regulation of cellular processes such as protein degradation and cell cycle progression. The antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. By binding to the FBXO30 protein, this antibody enables the detection and analysis of FBXO30 in a variety of cell types, making it an essential component for investigations in cell biology and cancer research.
FBXO30, a member of the F-box protein family, plays a crucial role in protein turnover through the ubiquitin-proteasome system, contributing to the control of cell growth and division. Dysregulation of FBXO30 has been implicated in various diseases, including cancer and neurodegenerative disorders, highlighting its potential as a therapeutic target. Studying the function of FBXO30 is essential for elucidating its role in health and disease, paving the way for the development of novel therapies targeting FBXO30-mediated pathways.
Western blot. All lanes: FBXO30 antibody at 10µg/ml + Mouse brain tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 83 kDa. Observed band size: 83 kDa.
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO39186 at dilution of 1:100.
Background:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.
Synonyms:
F-box only protein 30, FBXO30, FBX30
UniProt Protein Function:
FBXO30: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex.Protein type: Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 6q24Molecular Function: zinc ion bindingBiological Process: protein ubiquitination
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it is upregulated in nasopharyngeal carcinoma. [provided by RefSeq, Jul 2008]
