The FBXO22 Polyclonal Antibody (CAB8367) is a valuable tool for researchers studying the FBXO22 protein, which plays a critical role in the regulation of cellular processes, including protein degradation and cell cycle progression. This antibody, generated in rabbits, exhibits high specificity and sensitivity in detecting FBXO22 in various sample types, particularly human tissues.FBXO22 is a member of the F-box protein family, known for its role in targeting proteins for ubiquitination and subsequent degradation by the proteasome. Dysregulation of FBXO22 has been linked to various diseases, including cancer and neurodegenerative disorders, making it a promising target for therapeutic interventions.
The FBXO22 Polyclonal Antibody enables researchers to investigate the expression and function of FBXO22 in different cellular contexts, providing valuable insights into its role in disease development and progression. Its utility in techniques such as Western blotting and immunohistochemistry makes it an essential tool for studies in cell biology, oncology, and drug discovery.
Product Name:
FBXO22 Rabbit Polyclonal Antibody
SKU:
CAB8367
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 104-403 of human FBXO22 (NP_671717.1).
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
26263
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using FBXO22 antibody (CAB8367) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
