FBXO22 Rabbit Polyclonal Antibody (CAB8367)
- SKU:
- CAB8367
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
Product Name: | FBXO22 Rabbit Polyclonal Antibody |
SKU: | CAB8367 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 104-403 of human FBXO22 (NP_671717.1). |
Sequence: | YMAD SETF ISLE ECRG HKRA RKRT SMET ALAL EKLF PKQC QVLG IVTP GIVV TPMG SGSN RPQE IEIG ESGF ALLF PQIE GIKI QPFH FIKD PKNL TLER HQLT EVGL LDNP ELRV VLVF GYNC CKVG ASNY LQQV VSTF SDMN IILA GGQV DNLS SLTS EKNP LDID ASGV VGLS FSGH RIQS ATVL LNED VSDE KTAE AAMQ RLKA ANIP EHNT IGFM FACV GRGF QYYR AKGN VEAD AFRK FFPS VPLF GFFG NGEI GCDR IVTG NFIL RKCN EVKD DDLF HSYT TIMA LIHL GSSK |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | FBX22; FISTC1; FBXO22 |
Positive Sample: | HeLa,MCF-7 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Z line, myofibril, sarcomere. |
Calculated MW: | 45kDa |
Observed MW: | 45kDa |
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 26263 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |