The FBXO21 Polyclonal Antibody (CAB16107) is a valuable tool for researchers studying FBXO21, a critical protein involved in regulating cellular processes such as protein degradation and cell cycle progression. This antibody is raised in rabbits and has been validated for use in various applications, including Western blotting and immunofluorescence.FBXO21 is known to be a component of the SCF (SKP1-CUL1-F-Box) E3 ubiquitin ligase complex, which plays a crucial role in targeting proteins for degradation. It is also involved in regulating the stability of key proteins that control cell division. Research has shown that abnormalities in FBXO21 expression may be associated with certain diseases, including cancer and neurodegenerative disorders.
By using the FBXO21 Polyclonal Antibody, researchers can detect and analyze the expression levels and localization of FBXO21 in different cell types and tissues. This information is essential for understanding the function of FBXO21 in normal cellular processes and disease states. Ultimately, this antibody can help advance our knowledge of FBXO21 biology and potentially lead to the development of new therapeutic strategies for diseases linked to FBXO21 dysregulation.
Product Name:
FBXO21 Rabbit Polyclonal Antibody
SKU:
CAB16107
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 440-621 of human FBXO21 (NP_055817.1).
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.
Purification Method:
Affinity purification
Gene ID:
23014
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using FBXO21 Rabbit pAb (CAB16107) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
