The FBXO2 Polyclonal Antibody (CAB8579) is a valuable tool for researchers studying FBXO2, a F-box protein that plays a key role in the ubiquitin-proteasome system. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blotting applications. By specifically binding to the FBXO2 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an excellent choice for investigations in the fields of molecular biology and cellular physiology.FBXO2 is a crucial component in the regulation of protein degradation through the ubiquitin-proteasome pathway, making it essential for maintaining cellular homeostasis and controlling the levels of key signaling proteins.
Dysregulation of FBXO2 has been implicated in various diseases, including cancer and neurodegenerative disorders, highlighting its potential as a therapeutic target. By studying the functions of FBXO2, researchers can gain insights into the mechanisms underlying these pathologies and potentially identify novel treatment strategies.
Product Name:
FBXO2 Rabbit Polyclonal Antibody
SKU:
CAB8579
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-296 of human FBXO2 (NP_036300.2).
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state.
Purification Method:
Affinity purification
Gene ID:
26232
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using FBXO2 antibody (CAB8579) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
