The FBXO15 Monoclonal Antibody (PAC039134) is a valuable tool for researchers studying FBXO15, a key protein involved in cellular processes such as protein degradation and cell cycle regulation. This antibody, produced in mice, is highly specific to FBXO15 and has been validated for use in applications such as immunofluorescence and flow cytometry.FBXO15 is a member of the F-box protein family, known for its role in targeting specific proteins for degradation through the ubiquitin-proteasome pathway. Research has shown that FBXO15 is involved in regulating the stability of important proteins that control cell division and growth, making it a promising target for drug development in cancer and other diseases.
By using the FBXO15 Monoclonal Antibody, researchers can detect and study the expression and localization of FBXO15 in various cell types and tissues, providing valuable insights into its function and potential therapeutic applications. This antibody is a reliable tool for advancing our understanding of FBXO15 and its role in cellular physiology and disease pathogenesis.
Antibody Name:
FBXO15 Antibody (PACO39134)
Antibody SKU:
PACO39134
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human F-box only protein 15 protein (201-434AA)
Immunohistochemistry of paraffin-embedded human testis tissue using PACO39134 at dilution of 1:100.
Background:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Synonyms:
F-box only protein 15, FBXO15, FBX15
UniProt Protein Function:
FBXO15: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 18q22.3
UniProt Protein Details:
NCBI Summary:
Members of the F-box protein family, such as FBXO15, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
