The FBXO15 Polyclonal Antibody (PACO09250) is a valuable tool for researchers studying FBXO15, a protein involved in the regulation of cell division and protein degradation processes. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the FBXO15 protein, this antibody allows for the precise detection and analysis of this important molecule in various cell types.FBXO15 is a key player in the maintenance of cellular homeostasis, influencing cell cycle progression and protein turnover.
Dysregulation of FBXO15 has been linked to various diseases, including cancer and neurodegenerative disorders, making it a promising target for therapeutic interventions. Research into the functions of FBXO15 is essential for gaining insights into disease mechanisms and developing novel treatment strategies.Overall, the FBXO15 Polyclonal Antibody (PACO09250) offers researchers a reliable tool for investigating the role of FBXO15 in cellular processes and disease pathology, ultimately contributing to advances in biomedicine and drug development.
FBXO15: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 18q22.3
UniProt Protein Details:
NCBI Summary:
Members of the F-box protein family, such as FBXO15, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
