The FBXL8 Polyclonal Antibody (PACO09249) is a powerful tool for researching FBXL8, a protein involved in the regulation of cellular processes and gene expression. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot applications. By binding to the FBXL8 protein, researchers can easily detect and analyze its expression in various cell types, facilitating studies in molecular biology and cancer research.FBXL8 is a key player in the control of cell growth, apoptosis, and DNA damage response pathways, making it a promising target for investigating diseases such as cancer and metabolic disorders.
Understanding the function of FBXL8 can provide valuable insights into the mechanisms underlying these conditions, potentially leading to the development of targeted therapies. With its reliable performance and versatility, the FBXL8 Polyclonal Antibody is a valuable tool for unraveling the complexities of cellular regulation and disease progression.
F-box and leucine-rich repeat protein 8;FBXL8;FBL8;FLJ11278;MGC19959 ;
UniProt Protein Function:
FBXL8: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex.Chromosomal Location of Human Ortholog: 16q22.1Cellular Component: cytosolMolecular Function: protein binding; ubiquitin-protein ligase activityBiological Process: protein polyubiquitination
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. It shares 78% sequence identity with the mouse protein. [provided by RefSeq, Jul 2008]
