UniProt Protein Function: | FBXL8: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex.Chromosomal Location of Human Ortholog: 16q22.1Cellular Component: cytosolMolecular Function: protein binding; ubiquitin-protein ligase activityBiological Process: protein polyubiquitination |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. It shares 78% sequence identity with the mouse protein. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q96CD0 |
NCBI GenInfo Identifier: | 38257737 |
NCBI Gene ID: | 55336 |
NCBI Accession: | Q96CD0.1 |
UniProt Secondary Accession: | Q96CD0,Q9NUM0 |
UniProt Related Accession: | Q96CD0 |
Molecular Weight: | 40,516 Da |
NCBI Full Name: | F-box/LRR-repeat protein 8 |
NCBI Synonym Full Names: | F-box and leucine rich repeat protein 8 |
NCBI Official Symbol: | FBXL8Â Â |
NCBI Official Synonym Symbols: | FBL8Â Â |
NCBI Protein Information: | F-box/LRR-repeat protein 8 |
UniProt Protein Name: | F-box/LRR-repeat protein 8 |
UniProt Synonym Protein Names: | F-box and leucine-rich repeat protein 8; F-box protein FBL8 |
Protein Family: | F-box/LRR-repeat protein |
UniProt Gene Name: | FBXL8Â Â |
UniProt Entry Name: | FBXL8_HUMAN |