The FBXL5 Polyclonal Antibody (CAB5602) is a valuable tool for researchers studying FBXL5, a critical protein involved in iron metabolism and cellular homeostasis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the FBXL5 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for studies in biochemistry, molecular biology, and physiology.FBXL5 is a key player in the regulation of cellular iron levels, functioning as an E3 ubiquitin ligase that targets iron regulatory proteins for degradation.
Dysregulation of FBXL5 has been implicated in various diseases, including iron overload disorders and cancer. By further understanding the molecular mechanisms and functions of FBXL5, researchers can gain valuable insights into disease pathology and potentially develop novel therapeutic strategies targeting iron metabolism.Overall, the FBXL5 Polyclonal Antibody (CAB5602) provides a reliable tool for investigating the role of FBXL5 in iron homeostasis and disease pathogenesis, ultimately contributing to advancements in biomedical research and potential therapeutic interventions.
Product Name:
FBXL5 Rabbit Polyclonal Antibody
SKU:
CAB5602
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human FBXL5 (NP_036293.1).
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus.
Purification Method:
Affinity purification
Gene ID:
26234
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using FBXL5 Rabbit pAb (CAB5602) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
