The FBXL22 Polyclonal Antibody (PAC047962) is a valuable tool for researchers studying FBXL22, a protein involved in the regulation of cellular processes. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the FBXL22 protein, this antibody enables the detection and analysis of FBXL22 in various cell types, making it ideal for investigations in molecular biology and cell signaling pathways.FBXL22 is known to play a role in protein degradation and cell cycle regulation, making it a promising target for research on cancer and other diseases characterized by dysregulated cellular proliferation.
Understanding the function of FBXL22 can provide insights into the mechanisms underlying these conditions and may lead to the development of targeted therapies.Overall, the FBXL22 Polyclonal Antibody offers researchers a reliable tool for investigating the role of FBXL22 in cellular processes and disease pathways, advancing our understanding of potential therapeutic targets.
Western Blot. Positive WB detected in: Mouse brain tissue, Human placenta tissue. All lanes: FBXL22 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 28 kDa. Observed band size: 28 kDa..
Immunofluorescent analysis of Hela cells using PACO47962 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO47962 at dilution of 1:100.
Background:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC).
Synonyms:
F-box and leucine-rich protein 22, FBXL22
UniProt Protein Function:
FBXL22: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.Chromosomal Location of Human Ortholog: 15q22.31Biological Process: proteasomal ubiquitin-dependent protein catabolic process
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the F-box protein family. This F-box protein interacts with S-phase kinase-associated protein 1A and cullin in order to form SCF complexes which function as ubiquitin ligases.[provided by RefSeq, Sep 2010]
