The FBXL19 Polyclonal Antibody (PACO50682) is a valuable tool for researchers studying the FBXL19 protein, a member of the F-box protein family involved in regulating protein degradation and cell cycle progression. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to FBXL19, this antibody enables precise detection and analysis of the protein in a variety of cell types, making it ideal for investigations in cell biology and cancer research.FBXL19 is known for its role in targeting specific proteins for ubiquitination and subsequent degradation by the proteasome, ultimately influencing important cellular processes such as cell division and growth.
Understanding the function of FBXL19 is essential for unraveling its impact on various physiological and pathological conditions, including cancer development and progression. Research involving FBXL19 could lead to the identification of novel therapeutic targets for cancer treatment and other diseases influenced by dysregulated protein degradation pathways.Overall, the FBXL19 Polyclonal Antibody (PACO50682) is a valuable asset for researchers interested in exploring the intricate mechanisms of protein regulation and degradation, with potential implications for targeting cancer and other diseases at the molecular level.
Antibody Name:
FBXL19 Antibody (PACO50682)
Antibody SKU:
PACO50682
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human F-box/LRR-repeat protein 19 protein (4-259AA)
Immunofluorescent analysis of A549 cells using PACO50682 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Synonyms:
F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19), FBXL19, FBL19
UniProt Protein Function:
FBXL19: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 16p11.2Cellular Component: SCF ubiquitin ligase complexMolecular Function: protein bindingBiological Process: proteasomal ubiquitin-dependent protein catabolic process
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein is reported to bind to the transmembrane receptor interleukin 1 receptor-like 1 and regulate its ubiquitination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
