The FBXL18 Polyclonal Antibody (PACO09248) is a valuable tool for researchers studying FBXL18, a member of the F-box protein family involved in protein degradation and regulation of cell processes. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. By binding to the FBXL18 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential reagent for studies in cell biology and protein degradation pathways.FBXL18 has been implicated in various cellular processes, including cell cycle regulation, apoptosis, and DNA repair mechanisms. Its role in protein degradation through the ubiquitin-proteasome system highlights its importance in maintaining cellular homeostasis and proper functioning.
Research into FBXL18's function is essential for understanding its impact on cell physiology and potential implications in diseases like cancer, neurodegenerative disorders, and metabolic abnormalities.Overall, the FBXL18 Polyclonal Antibody (PACO09248) serves as a valuable tool for scientists seeking to explore the biological functions of FBXL18 and its role in cellular pathways. Its specificity and reliability make it an excellent choice for investigating the complex mechanisms underlying protein degradation and cell regulation.
F-box and leucine-rich repeat protein 18;FBXL18;FLJ10776;FLJ11467;FLJ26934;FLJ38075;FLJ41541;Fbl18 ;
UniProt Protein Function:
FBXL18: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 7p22.1Cellular Component: cytosolMolecular Function: ubiquitin-protein ligase activityBiological Process: post-translational protein modification; protein polyubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of a family of proteins that contain an approximately 40-amino acid F-box motif. This motif is important for interaction with SKP1 and for targeting some proteins for degradation. The encoded protein has been shown to control the cellular level of FBXL7, a protein that induces mitotic arrest, by targeting it for polyubiquitylation and proteasomal degradation. Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains. [provided by RefSeq, Mar 2016]
