The FBXL17 Polyclonal Antibody (PAC040702) is a valuable tool for researchers studying FBXL17, a protein involved in cell cycle regulation and tumor suppression. This antibody, produced in rabbits, has high specificity for human samples and is validated for use in Western blot applications. By binding to FBXL17, the antibody enables the detection and analysis of this protein in various cell types, making it an ideal choice for studies in cancer biology and cell signaling pathways.
FBXL17 is a member of the F-box protein family and plays a crucial role in controlling cell proliferation and apoptosis. Its tumor-suppressive properties make it a promising target for research aimed at understanding the mechanisms of cancer development and progression. By investigating the function of FBXL17, researchers can gain insights into potential therapeutic strategies for treating cancer and other related diseases.
Antibody Name:
FBXL17 Antibody (PACO40702)
Antibody SKU:
PACO40702
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human F-box/LRR-repeat protein 17 protein (1-303AA)
Immunohistochemistry of paraffin-embedded human colon cancer using PACO40702 at dilution of 1:100.
Background:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Synonyms:
F-box/LRR-repeat protein 17 (F-box and leucine-rich repeat protein 17) (F-box only protein 13), FBXL17, FBL17 FBX13 FBXO13
UniProt Protein Function:
FBXL17: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. 3 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 5q21.3
UniProt Protein Details:
NCBI Summary:
Members of the F-box protein family, such as FBXL17, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
