The FBXL13 Polyclonal Antibody (PACO09246) is a valuable tool for researchers studying FBXL13, a member of the F-box protein family that plays a role in the regulation of protein degradation. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the FBXL13 protein, this antibody allows for the detection and analysis of FBXL13 expression in various cell types, making it an ideal choice for studies in molecular biology and cell signaling.FBXL13 is known to be involved in the ubiquitin-proteasome pathway, where it targets specific proteins for degradation, thereby regulating important cellular processes such as cell cycle progression and signal transduction.
Understanding the function of FBXL13 is essential for unraveling its role in diseases such as cancer, neurodegenerative disorders, and metabolic diseases. By investigating the mechanisms by which FBXL13 influences protein turnover, researchers can gain valuable insights into potential therapeutic targets for these conditions.
F-box and leucine-rich repeat protein 13;FBXL13;FLJ38068;Fbl13;MGC21636 ;
UniProt Protein Function:
FBXL13: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 7q22.1
UniProt Protein Details:
NCBI Summary:
Members of the F-box protein family, such as FBXL13, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
