The FBXL12 Polyclonal Antibody (CAB14589) is a valuable tool for researchers studying FBXL12, a crucial protein involved in the regulation of cellular processes. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the FBXL12 protein, this antibody enables accurate detection and analysis in a variety of cell types.FBXL12 is known for its role in the ubiquitin-proteasome pathway, where it targets specific proteins for degradation, thus influencing various cellular functions such as cell cycle progression and gene expression.
Understanding the mechanisms of FBXL12 can provide insights into diseases like cancer, where deregulation of protein degradation pathways can lead to uncontrolled cell growth and proliferation.Researchers interested in exploring the functions of FBXL12 in cellular physiology and pathology will find the FBXL12 Polyclonal Antibody to be a valuable asset in their investigations. Its reliability and specificity make it an ideal choice for studies in molecular biology, oncology, and other fields related to protein regulation and cellular homeostasis.
Product Name:
FBXL12 Rabbit Polyclonal Antibody
SKU:
CAB14589
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-326 of human FBXL12 (NP_060173.1).
Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).
Purification Method:
Affinity purification
Gene ID:
54850
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using FBXL12 Rabbit pAb (CAB14589) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
