FBLN5 Rabbit Polyclonal Antibody (CAB9961)
- SKU:
- CAB9961
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | FBLN5 Rabbit Polyclonal Antibody |
SKU: | CAB9961 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 199-448 of human FBLN5 (NP_006320.2). |
Sequence: | NEDG RSCQ DVNE CATE NPCV QTCV NTYG SFIC RCDP GYEL EEDG VHCS DMDE CSFS EFLC QHEC VNQP GTYF CSCP PGYI LLDD NRSC QDIN ECEH RNHT CNLQ QTCY NLQG GFKC IDPI RCEE PYLR ISDN RCMC PAEN PGCR DQPF TILY RDMD VVSG RSVP ADIF QMQA TTRY PGAY YIFQ IKSG NEGR EFYM RQTG PISA TLVM TRPI KGPR EIQL DLEM ITVN TVIN FRGS SVIR LRIY VSQY PF |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:100 |
Synonyms: | EVEC; UP50; ADCL2; ARMD3; CMT1H; DANCE; ARCL1A; FIBL-5; HNARMD; FBLN5 |
Positive Sample: | A-431,Mouse lung,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted, extracellular matrix, extracellular space. |
Calculated MW: | 50kDa |
Observed MW: | 60kDa |
The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3).
Purification Method: | Affinity purification |
Gene ID: | 10516 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |