The FBLN1 Polyclonal Antibody (CAB16046) is a crucial tool for researchers studying fibulin-1, a key extracellular matrix protein involved in various biological processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the FBLN1 protein, researchers can accurately detect and analyze its expression in different cell types, making it an essential reagent for studies in cell biology, tissue development, and disease mechanisms.Fibulin-1 is known for its roles in cell adhesion, migration, and tissue organization, making it a significant player in processes like wound healing, angiogenesis, and cancer progression.
Its interaction with various proteins within the extracellular matrix also suggests its involvement in modulating cell signaling pathways and influencing cell behavior. Therefore, investigating the function of fibulin-1 using the FBLN1 Polyclonal Antibody is vital for understanding its impact on physiological and pathological conditions, such as fibrosis, cardiovascular diseases, and tumorigenesis. This antibody serves as a valuable tool for deciphering the complex roles of fibulin-1 in health and disease, paving the way for potential therapeutic interventions targeting this important protein.
Product Name:
FBLN1 Rabbit Polyclonal Antibody
SKU:
CAB16046
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 570-670 of human FBLN1 (NP_001987.2).
Secreted, extracellular matrix, extracellular space
Calculated MW:
77kDa
Observed MW:
77kDa
Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants.
Purification Method:
Affinity purification
Gene ID:
2192
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using FBLN1 Rabbit pAb (CAB16046) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
