Fibrillarin/U3 RNP Rabbit Polyclonal Antibody (CAB13490)
- SKU:
- CAB13490
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | Fibrillarin/U3 RNP Rabbit Polyclonal Antibody |
SKU: | CAB13490 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat,Monkey |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-321 of human Fibrillarin/U3 RNP (NP_001427.2). |
Sequence: | RGKE DALV TKNL VPGE SVYG EKRV SISE GDDK IEYR AWNP FRSK LAAA ILGG VDQI HIKP GAKV LYLG AASG TTVS HVSD IVGP DGLV YAVE FSHR SGRD LINL AKKR TNII PVIE DARH PHKY RMLI AMVD VIFA DVAQ PDQT RIVA LNAH TFLR NGGH FVIS IKAN CIDS TASA EAVF ASEV KKMQ QENM KPQE QLTL EPYE RDHA VVVG VYRP PPKV KN |
Tested Applications: | WB IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | FIB; FLRN; Nop1; RNU3IP1; Fibrillarin/U3 RNP |
Positive Sample: | HeLa,A375,U-2OS,COS-1,COS-7,PC-12,Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus, nucleolus. |
Calculated MW: | 34kDa |
Observed MW: | 37kDa |
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin.
Purification Method: | Affinity purification |
Gene ID: | 2091 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |