The FAT3 Polyclonal Antibody (PACO19018) is a valuable tool for researchers studying FAT3, a large cadherin-like transmembrane protein involved in cell migration and adhesion. This antibody, derived from rabbits, specifically targets the FAT3 protein in human samples and is optimized for Western blot applications. By binding to FAT3, this antibody allows for the visualization and analysis of FAT3 expression in various cell types, making it ideal for investigations in developmental biology and cancer research.
FAT3 plays a crucial role in the regulation of cell migration, cell-cell adhesion, and tissue morphogenesis, making it a key player in embryonic development and tumor progression. Research on FAT3 has implications for understanding diseases such as cancer, where aberrant cell migration and adhesion contribute to metastasis. By studying FAT3 expression and function, researchers can gain insights into potential therapeutic targets for controlling cell movement in cancer and other pathological conditions.
Antibody Name:
FAT3 Antibody (PACO19018)
Antibody SKU:
PACO19018
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human FAT3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19018(FAT3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19018(FAT3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
FAT1, FAT2, FAT3 and FAT4 are human homologs of Drosophila Fat, which is involved in tumor suppression and planar cell polarity (PCP). The atypical cadherin Fat3 ensures that retinal amacrine cells (ACs) develop this unipolar morphology. Fat3 expression was restricted to the nervous system, for example in the brain, it is expressed in a variety of regions and axon fascicles. However, its strongest expression was observed in the olfactory bulb and retina.
Synonyms:
FAT tumor suppressor homolog 3 (Drosophila)
UniProt Protein Function:
FAT3: May play a role in the interactions between neurites derived from specific subsets of neurons during development. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 11q14.3Cellular Component: integral to membrane; plasma membraneMolecular Function: calcium ion bindingBiological Process: multicellular organismal development; homophilic cell adhesion
