The FASLG Polyclonal Antibody (CAB0234) is a valuable tool for researchers studying FASLG, a protein involved in regulating immune responses and apoptosis. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications. By specifically binding to the FASLG protein, this antibody enables precise detection and analysis in a variety of cell types, making it well-suited for investigations in immunology and cancer research.
FASLG, also known as Fas ligand or CD178, plays a crucial role in programmed cell death and immune system regulation. Its involvement in apoptosis and immune response modulation has made it a target of interest in studies related to cancer, autoimmune diseases, and inflammatory conditions. Understanding the function and expression of FASLG is key to developing new therapeutic strategies that modulate immune responses and promote cell survival in disease settings.
Product Name:
FasLG Rabbit Polyclonal Antibody
SKU:
CAB0234
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 101-200 of human FasLG (NP_000630.1).
Cell membrane, Cytoplasmic vesicle lumen, Lysosome lumen, Nucleus, Secreted, Single-pass type II membrane protein.
Calculated MW:
31kDa
Observed MW:
41kDa
This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described.
Purification Method:
Affinity purification
Gene ID:
356
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and 293T cells transfected with FasLG using FasLG Rabbit pAb(CAB0234) at 1:600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
