The FAR2 Polyclonal Antibody (PAC016315) is a valuable tool for researchers studying FAR2, a key enzyme involved in fatty acid metabolism. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting FAR2 in a variety of samples. Validated for use in Western blot applications, it binds specifically to the FAR2 protein, enabling precise analysis in various cell types.FAR2, also known as fatty acyl-CoA reductase 2, plays a crucial role in lipid metabolism by catalyzing the reduction of fatty acyl-CoA to fatty alcohols. Dysregulation of FAR2 has been implicated in various metabolic disorders, making it a promising target for therapeutic interventions.
By studying the expression and activity of FAR2, researchers can gain insight into the mechanisms underlying lipid metabolism and potentially identify novel treatment strategies for metabolic diseases.Overall, the FAR2 Polyclonal Antibody is a reliable research tool for investigating the role of FAR2 in lipid metabolism and its implications in metabolic disorders. Its high reactivity and specificity make it ideal for studies in biochemistry, pharmacology, and metabolic diseases.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16315(FAR2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal liver tissue, Primary antibody: PACO16315(FAR2 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16315(FAR2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase enzyme involved in the first step of wax biosynthesis wherein fatty acid, are converted to fatty alcohols. The encoded peroxisomal protein utilizes saturated fatty acid, of 16 or 18 carbons as preferred substrates. Alternatively spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on chromosomes 2, 14 and 22.
Synonyms:
fatty acyl CoA reductase 2
UniProt Protein Function:
MLSTD1: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. The preferred substrates are C16, C18, C18:1 and C18:2 but low activity can be observed with C10-C14 substrates. Belongs to the fatty acyl-CoA reductase family.Protein type: Oxidoreductase; Membrane protein, integral; EC 1.2.1.n2; Membrane protein, multi-passChromosomal Location of Human Ortholog: 12p11.22Cellular Component: peroxisomal membrane; peroxisomal matrix; endoplasmic reticulum membrane; integral to membrane; peroxisomeMolecular Function: long-chain-fatty-acyl-CoA reductase activityBiological Process: cellular lipid metabolic process; ether lipid biosynthetic process
UniProt Protein Details:
NCBI Summary:
This gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase enzyme involved in the first step of wax biosynthesis wherein fatty acids are converted to fatty alcohols. The encoded peroxisomal protein utilizes saturated fatty acids of 16 or 18 carbons as preferred substrates. Alternatively spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on chromosomes 2, 14 and 22. [provided by RefSeq, Nov 2012]
