FAR1 Rabbit Polyclonal Antibody (CAB16284)
- SKU:
- CAB16284
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | FAR1 Rabbit Polyclonal Antibody |
SKU: | CAB16284 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human FAR1 (NP_115604.1). |
Sequence: | MVSI PEYY EGKN VLLT GATG FLGK VLLE KLLR SCPK VNSV YVLV RQKA GQTP QERV EEVL SGKL FDRL RDEN PDFR EKII AINS ELTQ PKLA LSEE DKEV |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | CSPSD; PFCRD; MLSTD2; SDR10E1; FAR1 |
Positive Sample: | Daudi,HepG2(Negative control) |
Conjugate: | Unconjugated |
Cellular Localization: | peroxisome |
Calculated MW: | 59kDa |
Observed MW: | 55kDa |
The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13.
Purification Method: | Affinity purification |
Gene ID: | 84188 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |