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Fibroblast activation protein-alpha (FAP) Antibody (CAB6349)

SKU:
CAB6349
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cardiovascular
  • Cardiovascular Antibodies Anti-FAP Antibody CAB6349
  • Cardiovascular Antibodies Anti-FAP Antibody CAB6349
€139 - €419
Frequently bought together:

Description

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Anti-FAP Antibody (CAB6349)

The FAP Polyclonal Antibody (CAB6349) is a valuable tool for researchers studying fibroblast activation protein (FAP), a cell surface glycoprotein that is highly expressed in cancer-associated fibroblasts. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including immunofluorescence and immunohistochemistry.FAP is known to play a key role in tumor progression and metastasis, making it a promising target for cancer therapy.

By specifically binding to FAP, this antibody enables the detection and analysis of FAP expression in different cell types, offering insights into its function in cancer biology. Researchers can use this antibody to investigate the potential of targeting FAP for therapeutic purposes in cancer treatment.Overall, the FAP Polyclonal Antibody is a reliable tool for investigating the role of FAP in cancer and advancing research towards developing innovative treatment strategies for cancer patients.

Antibody Name:Anti-FAP Antibody
Antibody SKU:CAB6349
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 26-280 of human FAP (NP_004451.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 26-280 of human FAP (NP_004451.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LRPS RVHN SEEN TMRA LTLK DILN GTFS YKTF FPNW ISGQ EYLH QSAD NNIV LYNI ETGQ SYTI LSNR TMKS VNAS NYGL SPDR QFVY LESD YSKL WRYS YTAT YYIY DLSN GEFV RGNE LPRP IQYL CWSP VGSK LAYV YQNN IYLK QRPG DPPF QITF NGRE NKIF NGIP DWVY EEEM LATK YALW WSPN GKFL AYAE FNDT DIPV IAYS YYGD EQYP RTIN IPYP KAGA KNPV VRIF IIDT TYPA YVGP QEV
Gene ID:2191
Uniprot:Q12884
Cellular Location:Cell membrane, Cell projection, Cell surface, Cytoplasm, Membrane, Secreted, Single-pass type II membrane protein, Single-pass type II membrane protein, invadopodium membrane, lamellipodium membrane, ruffle membrane
Calculated MW:26kDa/87kDa
Observed MW:88kDa
Synonyms:FAP, DPPIV, FAPA, FAPalpha, SIMP
Background:The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:FAP: In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers. Belongs to the peptidase S9B family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.4.14.5; Protease; EC 3.4.21.26; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q23

Cellular Component: apical part of cell; cell surface; cytoplasm; extracellular space; focal adhesion; integral to membrane; lamellipodium; plasma membrane

Molecular Function:dipeptidyl-peptidase activity; endopeptidase activity; integrin binding; metalloendopeptidase activity; peptidase activity; protease binding; protein binding; protein dimerization activity; protein homodimerization activity; serine-type endopeptidase activity; serine-type peptidase activity

Biological Process: angiogenesis; cell adhesion; endothelial cell migration; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of fibrinolysis

NCBI Summary:The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
UniProt Code:Q12884
NCBI GenInfo Identifier:292495099
NCBI Gene ID:2191
NCBI Accession:Q12884.5
UniProt Secondary Accession:Q12884,O00199, Q53TP5, Q86Z29, Q99998, Q9UID4,
UniProt Related Accession:Q12884
Molecular Weight:
NCBI Full Name:Prolyl endopeptidase FAP
NCBI Synonym Full Names:fibroblast activation protein alpha
NCBI Official Symbol:FAP  
NCBI Official Synonym Symbols:FAPA; SIMP; DPPIV  
NCBI Protein Information:prolyl endopeptidase FAP
UniProt Protein Name:Prolyl endopeptidase FAP
UniProt Synonym Protein Names:170 kDa melanoma membrane-bound gelatinase
Protein Family:Prolyl endopeptidase
UniProt Gene Name:FAP  
UniProt Entry Name:SEPR_HUMAN
Anti-FAP Antibody (CAB6349)Western blot analysis of extracts of mouse heart, using FAP antibody (CAB6349) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-FAP Antibody (CAB6349)Immunofluorescence analysis of U2OS cells using FAP antibody (CAB6349) at dilution of 1:100. Blue: DAPI for nuclear staining.

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