The FANK1 Polyclonal Antibody (PACO38018) is a valuable tool for researchers investigating the FANK1 protein, a key player in cellular processes related to DNA repair and replication. This antibody, generated in rabbits, exhibits high reactivity with human samples and is ideal for use in Western blotting applications. By specifically binding to the FANK1 protein, researchers can analyze its expression levels and distribution in various cell types, making it a versatile tool for studies in molecular biology and cancer research.FANK1, also known as FANCI-associated nuclease 1, plays a crucial role in maintaining genomic stability and preventing the accumulation of DNA damage.
Dysregulation of FANK1 has been implicated in various diseases, including cancer and genetic disorders. By understanding the function of FANK1, researchers can uncover potential therapeutic targets for diseases associated with DNA damage and replication errors.Overall, the FANK1 Polyclonal Antibody (PACO38018) is a valuable resource for researchers interested in elucidating the role of FANK1 in cellular processes and disease pathogenesis. Its high reactivity and specificity make it a reliable tool for studying the functions of FANK1 in various research settings.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO38018 at dilution of 1:100.
Immunofluorescence staining of MCF-7 cells with PACO38018 at 1:333, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes.
Synonyms:
Fibronectin type 3 and ankyrin repeat domains protein 1, FANK1
UniProt Protein Function:
FANK1: 3 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 10q26.2Cellular Component: cytoplasm; nucleoplasm
