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FANCI Rabbit Polyclonal Antibody (CAB3447)

SKU:
CAB3447
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Cycle
€139 - €419
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Description

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FANCI Rabbit Polyclonal Antibody (CAB3447)

The FANCI Polyclonal Antibody (CAB3447) is a powerful tool for researchers studying the FANCI protein, which plays a pivotal role in maintaining genomic stability and DNA repair. This antibody is produced in rabbits and specifically targets human samples, making it a reliable choice for Western blot applications. By binding to the FANCI protein, this antibody allows for the detection and analysis of FANCI expression in a variety of cell types, making it an invaluable asset for studies in molecular biology and cancer research.FANCI is a key component of the Fanconi Anemia (FA) pathway, a DNA repair pathway that safeguards against DNA damage and genomic instability.

Dysregulation of the FA pathway, including FANCI, has been linked to a variety of human diseases, including cancer and developmental disorders. By investigating the function of FANCI using this antibody, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets for their treatment. The FANCI Polyclonal Antibody (CAB3447) is a vital tool for unraveling the complexities of genomic maintenance and DNA repair.

Product Name:FANCI Rabbit Polyclonal Antibody
SKU:CAB3447
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1061-1328 of human FANCI (NP_001106849.1).
Sequence:DQDV EVEK TNHF AIVN LRTA APTV CLLV LSQA EKVL EEVD WLIT KLKG QVSQ ETLS EEAS SQAT LPNQ PVEK AIIM QLGT LLTF FHEL VQTA LPSG SCVD TLLK DLCK MYTT LTAL VRYY LQVC QSSG GIPK NMEK LVKL SGSH LTPL CYSF ISYV QNKS KSLN YTGE KKEK PAAV ATAM ARVL RETK PIPN LIFA IEQY EKFL IHLS KKSK VNLM QHMK LSTS RDFK IKGN ILDM VLRE DGED ENEE GTAS EHGG QNKE PAKK KRKK
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:KIAA1794; FANCI
Positive Sample:HeLa,293T,MCF7
Conjugate:Unconjugated
Cellular Localization:Nucleus.
Calculated MW:149kDa
Observed MW:149kDa

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group I. Alternative splicing results in two transcript variants encoding different isoforms.

Purification Method:Affinity purification
Gene ID:55215
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using FANCI antibody (CAB3447) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.

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