The FANCF Antibody (PAC016309) is a high-quality polyclonal antibody developed for research involving FANCF, a key protein involved in the Fanconi anemia DNA repair pathway. This antibody, derived from rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications. By specifically binding to the FANCF protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential tool for studies in genetics and cancer research.FANCF is crucial for maintaining genomic stability and preventing the accumulation of DNA damage that can lead to cancer development. Mutations in the FANCF gene are associated with Fanconi anemia, a rare genetic disorder characterized by bone marrow failure and an increased risk of cancer.
Research on FANCF is vital for understanding the mechanisms underlying DNA repair and how mutations in this gene contribute to disease development.By utilizing the FANCF Antibody (PAC016309), researchers can delve deeper into the functions of FANCF and its involvement in DNA repair processes. This antibody serves as a valuable tool for investigating the role of FANCF in cancer development and exploring potential therapeutic strategies for targeting this pathway in the treatment of genetic disorders.
Antibody Name:
FANCF Antibody (PACO16309)
Antibody SKU:
PACO16309
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
Fusion protein of human FANCF
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO16309(FANCF Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO16309(FANCF Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group F.
Synonyms:
Fanconi anemia, complementation group F
UniProt Protein Function:
FANCF: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Defects in FANCF are the cause of Fanconi anemia complementation group F (FANCF). A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.Protein type: DNA repair, damageChromosomal Location of Human Ortholog: 11p14.3Cellular Component: nucleoplasmMolecular Function: protein bindingDisease: Fanconi Anemia, Complementation Group F; Tracheoesophageal Fistula With Or Without Esophageal Atresia
UniProt Protein Details:
NCBI Summary:
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group F. [provided by RefSeq, Jul 2008]
