FANCF Antibody (PACO14413)
- SKU:
- PACO14413
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
FANCF Antibody (PACO14413)
The FANCF Antibody (PAC014413) is a polyclonal antibody developed for research purposes involving the FANCF protein, a key player in the Fanconi anemia pathway. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the FANCF protein, this antibody enables precise detection and analysis in various cell types, making it an invaluable tool for studies in genetics and oncology research.
FANCF is a critical component of the Fanconi anemia pathway, which is responsible for DNA repair and maintenance of genomic stability. Mutations in FANCF have been associated with Fanconi anemia, a rare genetic disorder characterized by bone marrow failure and increased cancer susceptibility. Understanding the function of FANCF is essential for advancing research into genetic disorders and cancer biology, ultimately paving the way for the development of targeted therapies and diagnostic tools.
| Antibody Name: | FANCF Antibody (PACO14413) |
| Antibody SKU: | PACO14413 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human FANCF |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO14413(FANCF Antibody) at dilution 1/100, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group F. |
| Synonyms: | Fanconi anemia, complementation group F |
| UniProt Protein Function: | FANCF: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Defects in FANCF are the cause of Fanconi anemia complementation group F (FANCF). A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.Protein type: DNA repair, damageChromosomal Location of Human Ortholog: 11p14.3Cellular Component: nucleoplasmMolecular Function: protein bindingDisease: Fanconi Anemia, Complementation Group F; Tracheoesophageal Fistula With Or Without Esophageal Atresia |
| UniProt Protein Details: | |
| NCBI Summary: | The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group F. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NPI8 |
| NCBI GenInfo Identifier: | 12232377 |
| NCBI Gene ID: | 2188 |
| NCBI Accession: | NP_073562.1 |
| UniProt Secondary Accession: | Q9NPI8,Q52LM0 |
| UniProt Related Accession: | Q9NPI8 |
| Molecular Weight: | 42,254 Da |
| NCBI Full Name: | Fanconi anemia group F protein |
| NCBI Synonym Full Names: | Fanconi anemia complementation group F |
| NCBI Official Symbol: | FANCFÂ Â |
| NCBI Official Synonym Symbols: | FAFÂ Â |
| NCBI Protein Information: | Fanconi anemia group F protein |
| UniProt Protein Name: | Fanconi anemia group F protein |
| UniProt Synonym Protein Names: | |
| Protein Family: | Fanconi anemia group F protein |
| UniProt Gene Name: | FANCFÂ Â |
| UniProt Entry Name: |
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