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FANCD2 Rabbit Monoclonal Antibody (CAB19692)

SKU:
CAB19692
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Cycle
$167 - $503
Frequently bought together:

Description

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FANCD2 Rabbit Monoclonal Antibody (CAB19692)

The FANCD2 Rabbit Monoclonal Antibody (CAB19692) is a cutting-edge research tool designed for studies involving the FANCD2 protein, a key player in the DNA repair pathway. This antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it an essential tool for researchers in the fields of genetics, oncology, and molecular biology.FANCD2 is essential for the repair of DNA damage, particularly in response to interstrand crosslinks, making it a crucial factor in maintaining genomic stability and preventing the development of genetic diseases such as Fanconi anemia. The FANCD2 Rabbit Monoclonal Antibody (CAB19692) enables the detection and analysis of FANCD2 protein levels in a variety of cell types, allowing researchers to investigate its role in DNA repair processes and its potential implications in cancer development.

By studying the function and regulation of FANCD2, researchers can gain deeper insights into the molecular mechanisms that govern genome stability and cellular response to DNA damage. This antibody serves as a valuable tool for advancing our understanding of DNA repair pathways and identifying potential targets for therapeutic intervention in cancer and other genetic disorders.

Product Name:FANCD2 Rabbit Monoclonal Antibody
SKU:CAB19692
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 200-300 of human FANCD2 (Q9BXW9).
Sequence:ISIA PENL QHDI ITSL PEIL GDSQ HADV GKEL SDLL IENT SLTV PILD VLSS LRLD PNFL LKVR QLVM DKLS SIRL EDLP VIIK FILH SVTA MDTL EVIS E
Tested Applications:WB IP ELISA
Recommended Dilution:WB,1:500 - 1:1000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:FA4; FAD; FACD; FAD2; FA-D2; FANCD; FANCD2
Positive Sample:K-562,HeLa,A549,C6,Mouse testis
Conjugate:Unconjugated
Cellular Localization:Nucleus.
Calculated MW:164kDa
Observed MW:166kDa

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:2177
Clone Number:ARC0172
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using FANCD2 Rabbit mAb (CAB19692) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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