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FANCD2 Rabbit Polyclonal Antibody (CAB2072)

SKU:
CAB2072
Product Type:
Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Cycle
  • Cell Cycle Antibodies 1 Anti-FANCD2 Antibody CAB2072
  • Cell Cycle Antibodies 1 Anti-FANCD2 Antibody CAB2072
  • Cell Cycle Antibodies 1 Anti-FANCD2 Antibody CAB2072
  • Cell Cycle Antibodies 1 Anti-FANCD2 Antibody CAB2072
€139 - €419
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Description

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FANCD2 Rabbit Polyclonal Antibody (CAB2072)

The FANCD2 Polyclonal Antibody (CAB2072) is a valuable tool for research on FANCD2, a key protein involved in the DNA repair pathway known as the Fanconi anemia pathway. This antibody, generated in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding to the FANCD2 protein, this antibody enables the detection and analysis of FANCD2 in various cell types, making it a crucial tool for studies in molecular biology and cancer research.FANCD2 plays a critical role in maintaining genomic stability and protecting cells from DNA damage. Mutations in the FANCD2 gene are associated with Fanconi anemia, a rare genetic disorder characterized by bone marrow failure and an increased risk of cancer.

Research on FANCD2 is essential for understanding the mechanisms of DNA repair and how defects in this pathway contribute to disease development.The FANCD2 Polyclonal Antibody is a valuable resource for researchers studying DNA repair mechanisms, cancer biology, and genetic diseases. Its high specificity and sensitivity make it an ideal choice for investigating the role of FANCD2 in maintaining genome integrity and preventing the onset of diseases linked to DNA damage.

Product Name:FANCD2 Rabbit Polyclonal Antibody
SKU:CAB2072
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 540-720 of FANCD2 (NP_001018125.1).
Sequence:AFSK QNEA SSHI QDDM HLVI RKQL SSTV FKYK LIGI IGAV TMAG IMAA DRSE SPSL TQER ANLS DEQC TQVT SLLQ LVHS CSEQ SPQA SALY YDEF ANLI QHEK LDPK ALEW VGHT ICND FQDA FVVD SCVV PEGD FPFP VKAL YGLE EYDT QDGI AINL LPLL FSQD FAKD GGPV TSQE S
Tested Applications:WB IF/ICC IP ELISA
Recommended Dilution:WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:FA4; FAD; FACD; FAD2; FA-D2; FANCD; FANCD2
Positive Sample:MCF7,HeLa,K-562,Jurkat,A-549,K-562
Conjugate:Unconjugated
Cellular Localization:Nucleus.
Calculated MW:164kDa
Observed MW:180kDa/164kDa

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:2177
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from K-562 cells using FANCD2 Rabbit pAb(CAB2072) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.

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