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FANCD2 Polyclonal Antibody (CAB21397)

SKU:
CAB21397
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€129 - €359
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Description

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FANCD2 Polyclonal Antibody (CAB21397)

The FANCD2 Polyclonal Antibody is a powerful tool for researchers studying FANCD2, a key protein involved in the Fanconi Anemia DNA repair pathway. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. It specifically binds to the FANCD2 protein, allowing for precise detection and analysis in a variety of cell types.FANCD2 is essential for maintaining genomic stability and preventing chromosomal abnormalities. Dysregulation of the Fanconi Anemia pathway, including FANCD2, is associated with an increased risk of cancer development.

Therefore, studying the function and regulation of FANCD2 is crucial for understanding the molecular mechanisms underlying cancer and identifying potential therapeutic targets.By using the FANCD2 Polyclonal Antibody in their research, scientists can gain valuable insights into the role of FANCD2 in DNA repair and genome maintenance. This antibody is an indispensable tool for investigations into genetic disorders, cancer biology, and personalized medicine strategies aimed at improving patient outcomes.

Product Name:FANCD2 Polyclonal Antibody
SKU:CAB21397
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human FANCD2 (NP_149075.2).
Sequence:MVSK RRLS KSED KESL TEDA SKTR KQPL SKKT KKSH IANE VEEN DSIF VKLL KISG IILK TGES QNQL AVDQ IAFQ KKLF QTLR RHPS YPKI IEEF VSGL ESYI EDED SFRN CLLS CERL QDEE ASMG ASYS KSLI KLLL GIDI LQPA IIKT LFEK LPEY FFEN KNSD EINI PRLI VSQL KWLD RVVD GKDL TTKI MQLI SIAP ENLQ HDII TSLP EILG DSQH ADVG KE
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:FA4; FAD; FACD; FAD2; FA-D2; FANCD; FANCD2
Positive Sample:MCF7,HeLa,K-562,Jurkat
Conjugate:Unconjugated
Cellular Localization:Nucleus.
Calculated MW:164kDa
Observed MW:Refer to figures

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:2177
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using FANCD2 Rabbit pAb (CAB21397) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.

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