The FANCA Rabbit Monoclonal Antibody (CAB9529) is a valuable tool for researchers studying Fanconi Anemia, a genetic disorder characterized by bone marrow failure and an increased risk of cancer. This antibody, developed using rabbit monoclonal technology, is highly specific to the FANCA protein and is validated for use in various experimental techniques, including Western blot and immunohistochemistry.FANCA is a key component of the Fanconi anemia pathway, which is responsible for repairing DNA damage and maintaining genomic stability. Mutations in the FANCA gene can disrupt this pathway, leading to the cellular defects and increased cancer susceptibility seen in individuals with Fanconi Anemia.
By targeting the FANCA protein, researchers can better understand the mechanisms underlying this disorder and potentially develop new therapeutic strategies for its treatment. Overall, the FANCA Rabbit Monoclonal Antibody (CAB9529) is an essential tool for investigating the role of FANCA in DNA repair and cancer development, making it a valuable asset for researchers in the fields of genetics, oncology, and molecular biology.
Product Name:
FANCA Rabbit Monoclonal Antibody
SKU:
CAB9529
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 2-104 of human FANCA (O15360).
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia.
Purification Method:
Affinity purification
Gene ID:
2175
Clone Number:
ARC1620
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using FANCA Rabbit mAb (CAB9529) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
