The FAM161A Polyclonal Antibody (PAC035946) is a valuable tool for researchers studying FAM161A, a protein involved in DNA repair and maintenance. This antibody, generated in rabbits, shows high specificity and reactivity with human samples, making it an ideal choice for Western blot experiments. By targeting the FAM161A protein, researchers can analyze its expression and function in various cellular processes, particularly in the context of DNA damage response and genome stability.FAM161A plays a crucial role in maintaining genomic integrity by participating in DNA repair mechanisms, which are essential for protecting cells from mutations and preserving genetic information.
Dysregulation of FAM161A has been linked to increased susceptibility to DNA damage and genomic instability, making it a potential target for studying diseases such as cancer and neurodegenerative disorders. By understanding the functions of FAM161A, researchers can gain insight into the molecular mechanisms underlying these conditions and potentially identify novel therapeutic strategies.
Western blot. All lanes: FAM161A antibody at 8µg/ml. Lane 1: Human placenta tissue. Lane 2: Mouse liver tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 77, 65, 84 kDa. Observed band size: 77 kDa.
Immunohistochemistry of paraffin-embedded human lung tissue using PACO35946 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human colon cancer using PACO35946 at dilution of 1:100.
Background:
Involved in ciliogenesis.
Synonyms:
Protein FAM161A, FAM161A
UniProt Protein Function:
FAM161A: Defects in FAM161A are the cause of retinitis pigmentosa type 28 (RP28). A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Belongs to the FAM161 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: CytoskeletalChromosomal Location of Human Ortholog: 2p15Cellular Component: centrosome; cytoplasm; photoreceptor connecting ciliumMolecular Function: protein bindingBiological Process: visual perception; response to stimulus; cilium biogenesisDisease: Retinitis Pigmentosa 28
UniProt Protein Details:
NCBI Summary:
This gene belongs to the FAM161 family. It is expressed mainly in the retina. Mouse studies suggested that this gene is involved in development of retinal progenitors during embryogenesis, and that its activity is restricted to mature photoreceptors after birth. Mutations in this gene cause autosomal recessive retinitis pigmentosa-28. Alternatively spliced transcript variants have been identified.[provided by RefSeq, Jan 2011]
