The FAM13B Polyclonal Antibody (PAC019643) is a valuable tool for researchers studying FAM13B, a gene associated with various physiological processes, including cell growth and migration. This antibody, produced in rabbits, exhibits high reactivity with human samples and is specifically validated for use in Western blot applications. By binding to the FAM13B protein, this antibody enables precise detection and analysis in a variety of cell types, making it well-suited for investigations in cellular biology and disease research.
FAM13B, also known as Family with Sequence Similarity 13 Member B, is known for its role in cell signaling pathways and has been implicated in diseases such as cancer and pulmonary disorders. Its involvement in regulating cell functions makes it an important target for studying molecular mechanisms underlying these conditions. Understanding the function of FAM13B is essential for developing targeted therapies and interventions that could potentially impact disease progression and treatment outcomes.
Antibody Name:
FAM13B Antibody (PACO19643)
Antibody SKU:
PACO19643
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human FAM13B
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO19643(FAM13B Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19643(FAM13B Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
FAM13B is a 915 amino acid, protein that is encoded by a gene that maps to human chromosome 5. With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6% of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
Synonyms:
family with sequence similarity 13, member B
UniProt Protein Function:
FAM13B: a protein that contains 1 Rho-GAP domain.Protein type: GAPs, Rac/Rho; GAPsChromosomal Location of Human Ortholog: 5q31Cellular Component: cytosolMolecular Function: GTPase activator activityBiological Process: positive regulation of defense response to virus by host; regulation of small GTPase mediated signal transduction
