The FAM111B Polyclonal Antibody (PACO09199) is a valuable tool for researchers studying the FAM111B protein, a key player in DNA replication and repair processes. This antibody, developed using rabbit immunization, exhibits high reactivity towards human samples and has been validated for use in Western blot applications. By specifically binding to the FAM111B protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in molecular biology and cancer research.FAM111B, also known as Family With Sequence Similarity 111 Member B, plays a crucial role in maintaining genomic stability through its involvement in DNA replication fidelity and repair mechanisms.
Dysregulation of FAM111B has been associated with genomic instability and is implicated in various diseases, including cancer and developmental disorders. Understanding the functions and regulatory mechanisms of FAM111B is essential for advancing our knowledge of DNA maintenance processes and identifying potential therapeutic targets for disease intervention.
family with sequence similarity 111, member B;FAM111B;CANP ;
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NCBI Summary:
This gene encodes a protein with a trypsin-like cysteine/serine peptidase domain in the C-terminus. Mutations in this gene are associated with an autosomal dominant form of hereditary fibrosing poikiloderma (HFP). Affected individuals display mottled pigmentation, telangiectasia, epidermal atrophy, tendon contractures, and progressive pulmonary fibrosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A paralog of this gene which also has a trypsin?like peptidase domain, FAM111A, is located only 16 kb from this gene on human chromosome 11q12.1. [provided by RefSeq, Apr 2014]
