The FAK Polyclonal Antibody (CAB21738) is a valuable tool for researchers studying focal adhesion kinase (FAK), a key player in cell signaling pathways related to cell adhesion, migration, and survival. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By targeting the FAK protein, this antibody allows for the detection and analysis of FAK expression in various cell types, making it an essential component in studies related to cell biology, cancer research, and drug development.
FAK has been identified as a critical regulator of cell motility and invasion, making it a promising therapeutic target for cancer treatment. Understanding the role of FAK in cancer progression and metastasis is essential for developing targeted therapies that can inhibit FAK activity and disrupt tumor growth. The FAK Polyclonal Antibody provides researchers with a reliable tool for investigating the functions of FAK in both normal and diseased cellular processes, ultimately paving the way for innovative approaches to cancer therapy.
Product Name:
FAK Polyclonal Antibody
SKU:
CAB21738
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 734-834 of human FAK (NP_722560.1).
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5747
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma using FAK Rabbit pAb (CAB21738) at dilution of 1:50 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
