The FAH Polyclonal Antibody (CAB13492) is a valuable tool for researchers studying the enzyme fumarylacetoacetate hydrolase (FAH), which is involved in the tyrosine catabolic pathway. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.FAH deficiency is a rare genetic disorder that results in the accumulation of toxic metabolites leading to liver and kidney damage. Research into FAH and its role in tyrosine metabolism is essential for understanding the pathophysiology of this disorder and developing treatments.
The FAH Polyclonal Antibody binds to the FAH enzyme, allowing for the detection and analysis of FAH levels in various cell types. Its application in immunoassays makes it a valuable tool for studying FAH expression patterns in normal and diseased tissues, as well as for investigating potential therapeutic strategies for FAH deficiency.
Product Name:
FAH Rabbit Polyclonal Antibody
SKU:
CAB13492
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-419 of human FAH (NP_000128.1).
Predicted to enable fumarylacetoacetase activity. Predicted to be involved in L-phenylalanine catabolic process; homogentisate catabolic process; and tyrosine catabolic process. Predicted to act upstream of or within arginine catabolic process. Located in extracellular exosome. Implicated in tyrosinemia type I.
Purification Method:
Affinity purification
Gene ID:
2184
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using FAH Rabbit pAb (CAB13492) at 1:7000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
